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Levitra)
Vardenafil (INN) is a PDE5 inhibitor used for treating impotence (erectile dysfunction) that is sold under the trade name Levitra (Bayer AG).
[edit] History
Vardenafil was co-marketed by Bayer Pharmaceuticals and GSK under the trade name Levitra. As of 2005, the co-promotion rights of GSK on Levitra have been returned to Bayer in many markets outside the U.S. In Italy, Bayer sells vardenafil as Levitra and GSK sells it as Vivanza, thus, because of European Union trade rules, parallel imports might result in Vivanza sold next to Levitra in the E.U.
[edit] Clinical use
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Main article: PDE5 inhibitor
Vardenafil's indications and contra-indications are the same as with other PDE5 inhibitor; it is closely related in function to sildenafil (Viagra) and tadalafil (Cialis). Structurally, the difference between a vardenafil molecule and the others is a methyl group and a nitrogen atom's position. Vardenafil's relatively short effective time is comparable to sildenafil's.
[edit] Adverse drug reactions
The common, adverse drug reactions (side effects) are the same as with other PDE5 inhibitors. The frequent vardenafil-specific side effect is nausea; the infrequent side effects are: abdominal pain, back pain, photosensitivity, abnormal vision, eye pain, facial oedema, hypertension, palpitation, tachycardia, arthralgia, myalgia, rash, itch, and priapism. (Rossi, 2004)
Using vardenafil also has been associated with suffering a heart attack as a serious side-effect. In rare cases, vardenafil use might damage penile tissue, resulting in permanent impotence. Health Canada (2006)
On 18 October 2007, the FDA announced that a warning about possible deafness (sudden hearing loss) would be added to the drug labels of Vardenafil, and other PDE5 inhibitors. [1]
[edit] Drug interactions
Vardenafil should not be used by men taking nitrate medications, because combining them with vardenafil might provoke potentially life-threatening hypotension (low blood pressure).
[edit] Dose forms
It is available in 2.5 mg, 5 mg, 10 mg, and 20 mg doses in round orange tablets. The normal starting dose is 10 mg (roughly equivalent to 50 mg of sildenafil). Vardenafil should be taken 1 to 2 hours prior to sexual activity, with a maximum dose frequency of once per day. In some territories, such as the UK, only certain doses may be available, i.e. 5 mg, 10 mg, and 20 mg.
[edit] Market structure
In 2000, Viagra sales acccounted for 92 per cent of global sales of prescribed impotence pills.(pdf)
[edit] See also
[edit] External links
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Urologicals (G04) |
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| Acidifiers |
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Urinary antispasmodics
(primarily antimuscarinics) |
Darifenacin, Emepronium, Fesoterodine, Flavoxate, Imidafenacin, Meladrazine, Oxybutynin, Propiverine, Solifenacin, Terodiline, Tolterodine, Trospium
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| For erectile dysfunction |
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| Other urologicals |
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| For BPH |
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